Product Information |
Product name |
(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine dihydrochloride ; Ibrutinib intermediate |
CAS No. |
1701403-10-2 |
Molecular Formula |
C22H24Cl2N6O |
Molecular Weight |
303.32 |
Quality Standard |
99% up by HPLC, GMP |
Appearance |
White powder |
Molecular Structure:
Synonyms: R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine dihydrochloride
Usage
Function of Ibrutinib
Ibrutinib is a chemotherapeutic agent, which is mainly used for
mantle cell lymphoma, chronic lymphocytic leukemia, small lymphocytic lymphoma
and Waldenstrom's macroglobulinemia. It can also be used for diseases such as
B-cell malignancies. The drug is a small molecule BTK inhibitor that can
inhibit the proliferation and survival of malignant B cells in vivo, as well as
cell migration and substrate adhesion in vitro. It cannot be taken with
grapefruit juice during the use of the drug, otherwise it will cause the drug
Absorb more. At the same time, the drug also has certain side effects, which
may cause bleeding in patients, increase the chance of infection, decrease
blood cells, interstitial lung disease, arrhythmia, hypertension, and secondary
malignant tumors. At the same time, pregnant women are not recommended to take
the drug, because the drug may damage the fetus, and the drug may also cause
skeletal muscle pain and joint pain.