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Polymyxin B Sulphate 1405-20-5

6500IU/MG up, USP

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Product Detail

Product Information

Product name	Polymyxin B Sulphate
CAS No.	1405-20-5
Molecular Formula	C56H100N16O17S
Molecular Weight	1301.56
Quality Standard	6500IU/MG up /Medicine Grade
Appearance	White powder

COA of Polymyxin B Sulphate

ITEMS	SPECIFICATION	RESULTS
DESCRIPTION	WHITE TO ALMOST WHITE POWDER, HYGROSCOPIC.	CONFORMS
SOLUBILITY	FREELY SOLUBLE IN WATER; SLIGHTLY SOLUBLE IN ALCOHOL.	CONFORMS
IDENTIFICATION	A. LIQUID CHROMATOGRAPHIC IDENTIFICATION TEST B. A REDDISH VIOLET COLOR IS PRODUCED C. TEST FOR SULFATE	CONFORMS
PH(2%)	5.0~7.0	5.7
PH(0.5%)	5.0~7.5	5.5
SPECIFIC ROTATION	-78°- -90°	-80.0°
LOSS ON DRYING	NOT MORE THAN 7.0%	4.7%
PHENYLALANINE	9.0%~12.0%	10.31%
SULPHATED ASH	NOT MORE THAN 0.75%	0.31%
SULPHATE	15.5%~17.5%	16.53%
HEAVY METALS	NOT MORE THAN 20PPM	<20PPM
ASSAY(MICROBIAL) (ON DRIED BASIS)	NOT LESS THAN 6500IU/MG	8220 IU/MG
PARTICLE SIZE	99.0%:NOT MORE THAN 30UM BY VOL. 90.0%:NOT MORE THAN 25UM BY VOL. 75.0%:NOT MORE THAN 20UM BY VOL. MEAN DIAMETER:NOT MORE THAN 8.0UM	CONFORMS
CONCLUSION:THE RESULTS CONFORM TO THE STANDARD OF USP34

Usage

Function of Polymyxin B Sulphate

Polymyxin B sulphate is similar to polymyxin E. It can inhibit gram-negative bacilli such as Escherichia coli, Pseudomonas aeruginosa, Para Escherichia coli, Klebsiella pneumoniae, Acidophilus, Pertussis and Shigella, etc. Or bactericidal effect. It is mainly used for Pseudomonas aeruginosa and other Pseudomonas to cause the wounds, urinary tract, eyes, ears, trachea and other parts of the Chemicalbook infection. It can also be used for sepsis and peritonitis. And resistant to aminoglycosides, resistant to third-generation cephalosporin bacteria and Pseudomonas aeruginosa or other sensitive bacteria caused by serious infections, such as bacteremia, endocarditis, pneumonia, post-burn infections, etc.

Polymyxin B is a peptide antibiotic against gram-negative bacilli, which can change the membrane structure to leak small molecules and inhibit the growth of gram-negative bacteria. Has a bactericidal effect on E. coli Chemicalbook. Binds to the lipid A portion of bacterial lipopolysaccharides. Inducing small holes in the outer cell membrane. Mode of action: Combine and interfere with the permeability of the cell plasma membrane. Antibacterial spectrum: Gram-negative bacteria.