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Penciclovir 39809-25-1

99% up by HPLC, GMP

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Product Detail

Product Information

Product name	Penciclovir
CAS No.	39809-25-1
Molecular Formula	C₁₀H₁₅N₅O₃
Molecular Weight	253.117
Quality Standard	99% up, GMP
Appearance	White or pale yellow powder

COA of Penciciovir

ITEMS	SPECIFICATIONS	RESULTS
Appearance	White or pale yellow crystalline powder	Complies
PH	5.5 to 7.5	6.5
Chloride	Not more than 0.015%	Complies
Related substances Total impurities	Not more than 1.0%	Complies
Loss on drying	Not more than 0.5%	Complies
Residue on ignition	Not more than 0.1%	Complies
Heavy metals	Not more than 0.002%	Complies
Assay	Not less than 99.0%,calculated on dried basis	99.6%
Conclusion	Complies with the specification

Usage

Function of Penciciovir

Penciclovir is a nucleoside antiviral drug, which has inhibitory effect on type I and type II herpes simplex virus in vitro. In virus-infected cells, viral thymidine kinase phosphorylates penciclovir to penciclovir monophosphate, and cell kinase converts penciclovir monophosphate to penciclovir triphosphate. In vitro experiments show that penciclovir triphosphate and deoxyguanosine triphosphate competitively inhibit herpes simplex virus polymerase, thereby selectively inhibiting herpes simplex virus DNA synthesis and inhibition. Therefore, penciclovir is suitable for the treatment of a variety of herpes virus infections. It has the characteristics of low toxicity and high virus sensitivity. Penciclovir has low oral absorption and is often used for topical administration. Famciclovir is a prodrug of penciclovir and is well absorbed orally.