Methoxypoly(ethylene glycol)-block-poly(glutamic acid) [mPEG-P(Glu)]

Methoxypoly(ethylene glycol)-block-poly(glutamic acid)

SINOPEG Biotech provides block copolymer derived from hydrophilic PEG and hydrophobic partners-usually stand for polyaspartic acid、polyglutamic acid 、poly(lactic-co-glycolic acid)、poly-D/L-lactide and propylene oxide. As a medical carrier, block copolymer can form micelle with PEG region in contact with surrounding solvent and partners in the center with insublable drug.

SINOPEG have the expertise and track record of producing scalable and convergent prodrugs for optimized preferential release with global clients.

Reference:

1. Matthew R. Golder.,etc., Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs, Nature Biomedical Engineering,2018,08

2. Matsumura Y, .,etc., Preclinical and clinical studies of anticancer agent-incorporating polymer micelles, Cancer Sci. 2009 Apr;100(4):572-9. Review.

3. Byeongmoon Jeong .,etc.,In situ gelation of PEG‐PLGA‐PEG triblock copolymer aqueous solutions and degradation thereof, Journal of Biomedical Materials Research, 50, 171–177, 2000.

4. Byeongmoon Jeong.,etc.,Thermoreversible Gelation of PEG-PLGA-PEG Triblock Copolymer Aqueous Solutions, Macromolecules199932217064-7069