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Metformin Hydrochloride 1115-70-4

98.5% up, EP/USP/BP

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Product Detail

Product Information

Product name	Metformin Hydrochloride; Metformin HCL
Molecular Formula	C4H12CIN5
Molecular Weight	165.62
CAS No.	1115-70-4
Quality Standard	98.5% -101.0%, EP/USP/BP Medical Grade
Appearance	White powder

COA of Metformin Hydrochloride

Tests	Specifications	Results
Appearance	White crystal	White crystal
Identifications	IR: complies with reference spectrum <197k> Identification test: it meets the requirements of the test for chloride <191>	Conforms
Related compounds	Cyanogunadine (Imp.A)≤0.02% Any other impurity≤0.1% Total impurities≤0.5%	0.001% 0.004% 0.01%
Heavy metals	≤0..001%<231>	<0.001%
Loss on drying	≤0.5%<731>	0.05%
Residue on ignition	≤0.1%<281>	0.03%
Residual solvents	Methanol≤3000ppm	380ppm
Assay (on anhydrous basis)	98.5% ~ 101.0%	99.8%
Conclusion: Conforms with USP37

Usage

Function of Metformin Hydrochloride

Metformin hydrochloride is a hypoglycemic drug, which is commonly used by patients with type II diabetes. At present, it is the first-line hypoglycemic drug recommended by Chinese guidelines and foreign guidelines. The main pharmacological effect is to inhibit liver glucose output and improve peripheral tissues’ insulin resistance. Sensitivity to glucose, increase glucose uptake and standby, so as to reduce blood sugar, metformin can reduce glycosylated hemoglobin by 1%-2%. In addition, metformin does not increase weight and does not cause hypoglycemia when used alone. This is also a relatively large advantage of metformin in terms of safety. Studies in recent years have shown that metformin has other effects besides lowering blood sugar, such as improving blood lipids, lowering triglyceride and cholesterol levels, and also reducing platelet aggregation, so it is beneficial to delay or improve vascular complications in diabetic patients . Metformin also has the effect of suppressing appetite, and many obese patients are more suitable to use metformin for weight loss. In short, metformin is a relatively effective drug for lowering blood sugar.