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LATANOPROST 130209-82-4

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Product Detail

Product Information

Product name	Latanoprost
Molecular Formula	C26H40O5
Molecular Weight	432.59
CAS No.	130209-82-4
Quality Standard	99% up, medical grade
Appearance	Light yellow oil

COA of Latanoporst

TESTS		SPECIFICATIONS	RESULTS
Description		Colorless or light yellow oil	Light yellow oil
Identification		A: IR B: The retention time of the major peak in the chromatogram of the sample corresponds to that of the standard solution, as obtained in the assay	Complies
Water		NMT 2.0%	0.05%
Optical rotation		+31°～+38°	+35.2°
Residue on ignition		NMT 0.5%	0.05%
Related substances (HPLC)	Isopropyl Dipheny lphosphorylpentanoate	NMT0.1%	0.06%
	Related compound B	NMT0.5%	0.09%
	Related compound A	NMT3.5%	N.D
	Any unspecified impurity	NMT0.1%	0.06%
	Total other impurities	NMT0.5%	0.08%
Related Compound E		NMT0.2%	0.02%
Residue Solvent	n-Hexane	NMT0.029%	Not detected
	Ethanol	NMT0.5%	0.15%
	Methanol	NMT0.3%	Not detected
	Isopropanol	NMT0.5%	Not detected
Assay		94.0%~102.0%	99.77%
Conclusion: The product complies as per above specification.

Usage

Function of Latanoprost

Latanoprost is a new type of phenyl substituted prostaglandin F2α, which is a selective F2α receptor agonist. It is an inactive substance that can quickly penetrate into the cornea and can be hydrolyzed into active free acids in the cornea and plasma. It can increase the outflow of aqueous humor through the corneal layer, and the amount of medication is small, but promotes the outflow of aqueous humor. This product can also smooth the trabecular meshwork structure of the glaucoma patients that are usually blocked.

Latanoprost is a new class of ocular hypotensive drugs developed in recent years and gradually applied to the clinic. Unlike other anti-glaucoma drugs, this product does not change the flow coefficient of the aqueous humor, the production of aqueous humor, and suprascleral venous pressure, but reduces the intraocular pressure by increasing the waterproofing from the uveal scleral passage and outflow.