Insulin Degludec Side Chain [L-tBuO-Pal-Glu(OSu)-OtBu]

Insulin Degludec Side Chain

Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Marketed as the brand name product Tresiba by Novo Nordisk in 2015, insulin degludec has an added C-16 fatty acid on lysine at the B29 position which allows for the formation of multi-hexamers.

SINOPEG is pleased to offer this C-16 fatty acid for your R&D and clinic research.

Reference:

1.  Garber AJ, etc.,: Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): a phase 3, randomised, open-label, treat-to-target non-inferiority trial. Lancet. 2012 Apr 21;379(9825):1498-507;

2.  Wang F, etc.,: Insulin degludec as an ultralong-acting basal insulin once a day: a systematic review. Diabetes Metab Syndr Obes. 2012;5:191-204;

3.  Haahr H, etc.,: A review of the pharmacological properties of insulin degludec and their clinical relevance. Clin Pharmacokinet. 2014 Sep;53(9):787-800;

4.  Jonassen I, Havelund S, Hoeg-Jensen T, Steensgaard DB, Wahlund PO, Ribel U: Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin. Pharm Res. 2012 Aug;29(8):2104-14;

5.  Thuillier P, etc: Long-term safety and efficacy of insulin degludec in the management of type 2 diabetes. Diabetes Metab Syndr Obes. 2015 Oct 1;8:483-93.