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ALPROSTADIL 745-65-3

95% up, USP26

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Product Detail

Product Information

Product name	Alprostadil
Molecular Formula	C20H34O5
Molecular Weight	354.48
CAS No.	745-65-3
Quality Standard	95% up, USP26
Appearance	White powder

COA of Alprostadil

Items	Specifications	Results
Appearance	White to off-white powder	Complies
Identification	HPLC retention time of sample complies with that of known sample	Complies
Water	≤0.5%	0.03%
Residual solvents	≤0.5%	0.02%
Residual on ignition	≤0.5%	0.20%
Related substances	PGAI:≤0.5%	Undetected
	PGBI:≤0.5%	Undetected
	13,14-Dihydro-PGEI: ≤0.5%	Undetected
	Other impurities: ≤ 0.5%	Undetected
Assay	95.0%~105.0%	99.00%

Usage

Function of Alprostadil
Alprostadil, alias PGE1. PGE1 is a biologically active substance widely present in the body, the mechanism of treating diabetic neuropathy:

1. Improve hemodynamics, increase the CAMP content in vascular smooth muscle cells, exert its vasodilator effect and reduce peripheral resistance;

2. To improve blood rheology, PGE can inhibit platelet aggregation, reduce platelet high response and thromboxane A (TXA) level, inhibit platelet activation, promote the reversal of activated platelets around thrombus, and improve the deformability of red blood cells;

3. PGE can activate lipoproteinase and promote triglyceride hydrolysis, reduce blood lipids and blood viscosity;

4. PGE can stimulate vascular endothelial cells to produce tissue-type fibrinolytic substance (t-PA), which has a certain direct thrombolytic effect.

5. By inhibiting free Caz of vascular smooth muscle cells and inhibiting the release of norepinephrine from vascular sympathetic nerve endings, the vascular smooth muscle is relaxed and the microcirculation is improved.