AFP(Alpha-fetoprotein) is a major plasma protein produced by the yolk sac and the fetal liver during fetal development. Serum AFP levels decrease rapid after birth. The normal range of AFP for adults serum is usually less than 10ng/mL. It may increase during pregnancy result from the blood collection to fetus and thus can be measured in pregnant women as a screening test for certain developmental abnormalities such as aneuploidy.
Additionally, serum AFP level is elevated in some pathological conditions such as hepatocellular carcinoma, metastatic disease affecting the liver or germ cell tumor. Therefore AFP is widely used as a biomarker for cancer and evaluation for cancer treatments [1-2].
CEA (Carcinoembryonic antigen) describes a set of highly related glycoproteins involved in cell adhesion. CEA is normally produced in gastrointestinal tissue during fetal development, but the production stops before birth. Consequently, CEA is usually present at very low levels in the blood of healthy adults.However, the serum levels are raised in some types of cancer, which means that it can be used as a tumor marker in
clinical tests [3]
Product Specification
|
Specimen Types |
Serum/ Plasma |
|
Specimen Capacity |
20μL |
|
Reaction Time |
10 min |
|
Sample Capacity |
80μL |
|
Detection Range |
Refer to individual item |
Advantages
Avoid hook effect
In the Tang screening test, alpha-fetoprotein (AFP) must be checked
Clinical significance
1. Differential diagnosis of acute hepatitis and cirrhosis
2. Important indicators for the diagnosis of primary liver cancer
3. Screening for congenital diseases such as Down syndrome, ectopic pregnancy, stillbirth, etc.
4. One of the important indicators for monitoring pregnancy
Intended use
Gastroenterology, Oncology, Hepatobiliary Surgery, Obstetrics and Gynecology, Urology, Male Surgery
Reference
1.Binxia Chang, Shaojie Xin. A fetoprotein and its clinical application research progress[J]. J of World Chinese Journal of Digestology, 2010, 18(6): 576-580.
2. Liqiang Hao,Yong Wan. New advances in the detection and clinical application of CEA[J]. J of Foreign Medical Sciences(section of Surgery) ,1999, 26(4): 197-199.
3. Weiwen Xu, Yingsong Wu, Jianfeng Hang, Congrong Wang, Guolan Zhang, Ming Li. Time-resolved immunofluorescence method for quantitative detection of cytoplasm antigen(CEA) reagent clinical application research[J]. J of Modern Laboratory Medicine, 2005, 20(6) :28 -31
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